High-Quality Binary Protein Interaction Map of the Yeast Interactome Network
نویسندگان
چکیده
منابع مشابه
Yeast Interactome Network High - Quality Binary Protein Interaction
www.sciencemag.org (this information is current as of October 2, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/322/5898/104 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1158684/DC1 can be found at: ...
متن کاملHigh-quality binary protein interaction map of the yeast interactome network.
Current yeast interactome network maps contain several hundred molecular complexes with limited and somewhat controversial representation of direct binary interactions. We carried out a comparative quality assessment of current yeast interactome data sets, demonstrating that high-throughput yeast two-hybrid (Y2H) screening provides high-quality binary interaction information. Because a large fr...
متن کاملComment on Yu et al.,"High Quality Binary Protein Interaction Map of the Yeast Interactome Network."Science 322, 104 (2008)
We test the claim by Yu et al. —presented in Science 322, 104 (2008)—that the degree distribution of the yeast (Saccharomyces cerevisiae) protein-interaction network is best approximated by a power law. Yu et al. consider three versions of this network. In all three cases, however, we find the most likely power-law model of the data is distinct from and incompatible with the one given by Yu et ...
متن کاملHigh-quality binary interactome mapping.
Physical interactions mediated by proteins are critical for most cellular functions and altogether form a complex macromolecular "interactome" network. Systematic mapping of protein-protein, protein-DNA, protein-RNA, and protein-metabolite interactions at the scale of the whole proteome can advance understanding of interactome networks with applications ranging from single protein functional ch...
متن کاملAn in vivo map of the yeast protein interactome.
Protein interactions regulate the systems-level behavior of cells; thus, deciphering the structure and dynamics of protein interaction networks in their cellular context is a central goal in biology. We have performed a genome-wide in vivo screen for protein-protein interactions in Saccharomyces cerevisiae by means of a protein-fragment complementation assay (PCA). We identified 2770 interactio...
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ژورنال
عنوان ژورنال: Science
سال: 2008
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1158684